AI-Designed Drug Targets Lung Scarring
Artificial intelligence helped researchers identify an enzyme target and design a drug candidate for idiopathic pulmonary fibrosis (IPF), a disease in which scarring progressively damages…
The science of enzymes. The possibilities they create.
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Dr. Matheus Regis Belisário Ferrari is the owner and editor of EnzymeNews. Based in Germany, he holds a PhD and has a research background in biotechnology, biochemistry, molecular biology and enzyme engineering. He uses AI tools to assist with article drafting and checks the articles against their original research sources before publication.
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Artificial intelligence helped researchers identify an enzyme target and design a drug candidate for idiopathic pulmonary fibrosis (IPF), a disease in which scarring progressively damages…
Researchers used CRISPR to change the composition and colour of a food fungus. The results show what pathway engineering can achieve—and what remains untested.
Patterns in natural protein sequences can help models suggest enzyme changes. A review explains the opportunity, the limits of prediction and why experiments matter.
A chemically modified lipase worked in a heated ionic liquid to break down PLA. The study separates plastic solubilisation from conversion into lactic acid.
A one-cow experiment detected human insulin-related protein in milk. Low output and analytical limits separate this proof of concept from a manufacturing process.
An experimental acne vaccine reduced skin inflammation in mice by targeting an enzyme made by certain strains of Cutibacterium acnes.
An evolutionary comparison suggests that Rubisco has gradually improved its performance in C₃ flowering plants. The findings offer clues for enzyme engineering, but crop-yield gains…
A study involving EvoEnzyme used FuncLib to redesign peroxygenases, creating variants with different product preferences and substrate-specific performance gains.
Cells and enzymes depend on one another today. RNA catalysts, chemical networks and protocell experiments offer clues to how that relationship could have begun.
Boosting a worm counterpart of G3PP improved movement with age and extended lifespan under excess glucose. Researchers traced a link to cellular recycling, with limits…
Living cells make many useful chemicals, but keeping those cells alive also adds work to a manufacturing process.
AlphaFold 2 helps researchers explore enzyme structures and plan experiments. Confidence scores and biological context determine what a prediction can usefully tell us.